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| Bill & Melinda Gates Foundation |
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| Bill & Melinda Gates Foundation was established in 2000 with $106 million. |
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| 2 |
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| Wellcome Trust |
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| Wellcome Trust was established in 1936 in London. |
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| 3 |
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| Howard Hughes Medical Institute |
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| Howard Hughes Medical Institute was founded in 1953 by Howard Hughes. |
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| 4 |
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| Lilly Endowment |
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| Lilly Endowment was established in 1937 by Josiah K. Lilly. |
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| 5 |
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| Ford Foundation |
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| Ford Foundation was founded in 1936 by Edsel Ford. |
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| 6 |
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| Robert Wood Johnson Foundation |
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| Robert Wood Johnson Foundation was established in 1936 by Robert Wood Johnson II. |
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| 7 |
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| W. K. Kellogg Foundation |
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| W. K. Kellogg Foundation was founded in 1930 by Will Keith Kellogg. |
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| 8 |
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| William and Flora Hewlett Foundation |
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| William and Flora Hewlett Foundation was founded in 1966 by Bill Hewlett. |
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