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This list contains the most largest U.S. charities of the world.
1
Academy for Educational Development
Academy for Educational Development
2
Alzheimer's Association
Alzheimer's Association
3
American Bible Society
American Bible Society
4
American Cancer Society
American Cancer Society
5
American Civil Liberties Union Foundation
American Civil Liberties Union Foundation
6
American Diabetes Association
American Diabetes Association
7
American Heart Association
American Heart Association
8
American Jewish Committee
American Jewish Committee
9
American Jewish Joint Distribution Committee
American Jewish Joint Distribution Committee
10
American Kidney Fund
American Kidney Fund
11
American Lung Association
American Lung Association
12
American Museum of Natural History
American Museum of Natural History
13
American National Red Cross
American National Red Cross
14
American Near East Refugee Aid
American Near East Refugee Aid
15
American Nicaraguan Foundation
American Nicaraguan Foundation
16
American SPCA
American SPCA
17
AmeriCares Foundation
AmeriCares Foundation
18
Anti-Defamation League of B'nai B'rith
Anti-Defamation League of B'nai B'rith
19
The Arc of the United States
The Arc of the United States
20
Art Institute of Chicago
Art Institute of Chicago
21
Arthritis Foundation
Arthritis Foundation
22
Aspen Institute
Aspen Institute
23
Billy Graham Evangelistic Association
Billy Graham Evangelistic Association
24
Boys & Girls Clubs of America
Boys & Girls Clubs of America
25
Brother's Brother Foundation
Brother's Brother Foundation
26
California Academy of Science
California Academy of Science
27
Campus Crusade for Christ
Campus Crusade for Christ
28
CARE USA
CARE USA
29
Carter Center
Carter Center
30
Catholic Charities USA
Catholic Charities USA
31
Catholic Medical Mission Board
Catholic Medical Mission Board
32
Catholic Relief Services
Catholic Relief Services
33
Children International
Children International
34
Children's Hospital
Children's Hospital
35
Children's Hospital Association
Children's Hospital Association
36
Children's Hospital Los Angeles
Children's Hospital Los Angeles
37
Children's Hospital of Philadelphia
Children's Hospital of Philadelphia
38
Children's Hunger Fund
Children's Hunger Fund
39
Children's Memorial Hospital
Children's Memorial Hospital
40
Children's National Medical Center
Children's National Medical Center
41
Children's Network International
Children's Network International
42
Christian & Missionary Alliance
Christian & Missionary Alliance
43
Christian Aid Ministries
Christian Aid Ministries
44
Christian Blind Mission International
Christian Blind Mission International
45
Christian Broadcasting Network
Christian Broadcasting Network
46
Christian Children's Fund
Christian Children's Fund
47
Christian Foundation for Children and Aging
Christian Foundation for Children and Aging
48
City of Hope
City of Hope
49
Cleveland Clinic Foundation
Cleveland Clinic Foundation
50
Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory